EPZ004777
Cat. No.：YN270302
CAS No. ：1338466-77-5
| 产品名称: | EPZ004777 |
| CAS No.: | 1338466-77-5 |
| Chemical Name: | 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; |
| Synonyms: | 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea;EPZ004777;0QK;EPZ-004777;S7032;7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl |
| 分子量: | 539.67 |
| 分子式: | C₂₈H₄₁N₇O₄ |
| SMILES: | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(C(C)C)CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)O3)C=C2)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EPZ004777 是一种有效的选择性DOT1L抑制剂，IC50为 0.4 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chen, L., et al.: Leukemia, 27, 813-822 (2013)
Yu, W., et al.: Bioorg, Med. Chem., 21, 1787-1794 (2013)
