Devimistat
Cat. No.：YN270303
CAS No. ：95809-78-2
| 产品名称: | Devimistat |
| CAS No.: | 95809-78-2 |
| Chemical Name: | 6,8-bis[(phenylmethyl)thio]-octanoic acid |
| Synonyms: | CPI-613 |
| 分子量: | 388.59 |
| 分子式: | C₂₂H₂₈O₂S₂ |
| SMILES: | O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Devimistat (CPI-613) 是一种硫辛酸类似物，可抑制丙酮酸脱氢酶 (PDH) 和α-酮戊二酸脱氢酶，破坏线粒体代谢 并显示出强大的抗肿瘤活性。 |
| IC50和靶点: | |
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Stuart, S.D., Schauble, A., Gupta, S., et al.A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox processCancer Metab.2(1),4(2014)
Lee, K.C., Shorr, R., Rodriguez, R., et al.Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolismDrug Metab. Lett.5(3),163-182(2011)
Zachar, Z., Marecek, J., Maturo, C., et al.Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivoJ. Mol. Med. (Berl.)89(11),1137-1148(2011)
Lee, K.C., Maturo, C., Perera, C.N., et al.Translational assessment of mitochondrial dysfunction of pancreatic cancer from in vitro gene microarray and animal efficacy studies, to early clinical studies, via the novel tumor-specific anti-mitochondrial agent, CPI-613Ann. Transl. Med.2(9),91(2014)
