EI1
Cat. No.：YN270312
CAS No. ：1418308-27-6
| 产品名称: | EI1 |
| CAS No.: | 1418308-27-6 |
| Chemical Name: | 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide |
| Synonyms: | KB-145943 |
| 分子量: | 390.48 |
| 分子式: | C₂₃H₂₆N₄O₂ |
| SMILES: | CCC(CC)N(C=C1)C2=C1C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C#N)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EI1 (KB-145943) 是一种新颖的，有效的EZH2抑制剂，能够作用于 EZH2 (WT) 和 EZH2 (Y641F)，IC50值分别为 15 nM 和 13 nM。 |
| IC50和靶点: | [{name:"EZH2 Y641F mutant type:13 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Simon, J.A., and Lange, C.A.Roles of the EZH2 histone methyltransferase in cancer epigeneticsMutat. Res.647(1-2),21-29(2008)
Qi, W., Chan, H.M., Teng, L., et al.Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferationProc. Natl. Acad. Sci. USA109(52),21360-21365(2012)
