TIC10
Cat. No.：YN270315
CAS No. ：1616632-77-9
| 产品名称: | TIC10 |
| CAS No.: | 1616632-77-9 |
| Chemical Name: | 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one |
| Synonyms: | ONC-201 |
| 分子量: | 386.49 |
| 分子式: | C₂₄H₂₆N₄O |
| SMILES: | O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TIC10 是一种有效，有口服活性，稳定的肿瘤坏死因子相关的凋亡诱导配体TRAIL诱导剂，其通过抑制Akt和ERK起作用，从而激活 Foxo3a 并显着诱导细胞表面 TRAIL。TIC10 可透过血脑屏障。 |
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Allen, J.E., Krigsfeld, G., Mayes, P.A., et al.Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effectsSci. Transl. Med.5(171),171ra117(2013)
