GSK-J4
Cat. No.：YN270316
CAS No. ：1373423-53-0
| 产品名称: | GSK-J4 |
| CAS No.: | 1373423-53-0 |
| Chemical Name: | |
| Synonyms: | GSK-J4 free base; GSK-J-4; GSK-J 4; GSK-J4; |
| 分子量: | 417.50 |
| 分子式: | C₂₄H₂₇N₅O₂ |
| SMILES: | O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK-J4 是一种有效的 H3K27me3/me2 去甲基化酶JMJD3/KDM6B和UTX/KDM6A双抑制剂，IC50分别为 8.6 μM 和 6.6 μM。GSK-J4 抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α，IC50值为 9 μM。GSK-J4 是 GSK-J1 的细胞通透性前药。GSK-J4 诱导内质网应激相关的细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
