Sodium 4-phenylbutyrate
Cat. No.：YN270318
| 产品名称: | Sodium 4-phenylbutyrate |
| CAS No.: | 1716-12-7 |
| Chemical Name: | benzenebutanoic acid, monosodium salt |
| Synonyms: | 苯丁酸钠; 4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium |
| 分子量: | 186.18 |
| 分子式: | C₁₀H₁₁NaO₂ |
| SMILES: | O=C(O[Na])CCCC1=CC=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sodium 4-phenylbutyrate (4-PBA sodium) 是一种组蛋白去乙酰化酶 (HDAC) 和内质网应激 (ERS) 抑制剂，可用于癌症和感染等疾病的研究。 |
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Stewart, G.A., Ridscale, R., Martin, E.P., et al.4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-CAm. J. Respir. Cell Mol. Biol.47(3),324-331(2012)
Bradbury, N.A.Focus on "sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of ΔF508-CFTR"Am. J. Physiol. Cell Physiol.278(2),C257-C258(2000)
Lu, Q., Wang, D.S., Chen, C.S., et al.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitorsJ. Med. Chem.48(17),5530-5535(2005)
Ammerpohl, O., Trauzold, A., Schniewind, B., et al.Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cellsBr. J. Cancer96(1),73-81(2007)
Griffiths, E.A., and Gore, S.D.DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromesSemin. Hematol.45(1),23-30(2008)
