NMS-1286937
Cat. No.：YN270320
CAS No. ：1034616-18-6
| 产品名称: | NMS-1286937 |
| CAS No.: | 1034616-18-6 |
| Chemical Name: | 4,5-dihydro-1-(2-hydroxyethyl)-8-[[5-(4-methyl-1-piperazinyl)-2-(trifluoromethoxy)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide |
| Synonyms: | NMS-P937 |
| 分子量: | 532.52 |
| 分子式: | C₂₄H₂₇F₃N₈O₃ |
| SMILES: | O=C(C1=NN(CCO)C2=C1CCC3=CN=C(NC4=CC(N5CCN(C)CC5)=CC=C4OC(F)(F)F)N=C23)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | nMS-1286937 是一种有效、高选择性、可口服的PLK1抑制剂，IC50值为 2 nM。 |
| IC50和靶点: | [{name:"PLK1:2 nM (IC50)"},{name: "FLT3:510 nM (IC50)"},{name: "MELK:744 nM (IC50)"},{name: "CK2:826 nM (IC50)"}] |
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| Solvent & Solubility: |
Beria, I., Bossi, R.T., Brasca, M.G., et al.NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitorBioorg. Med. Chem. Lett.21(10),2969-2974(2011)
Valsasina, B., Beria, I., Alli, C., et al.NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignanciesMol. Cancer Ther.11(4),1006-1016(2012)
