CPI-203
Cat. No.：YN270323
| 产品名称: | CPI-203 |
| CAS No.: | 1446144-04-2 |
| Chemical Name: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Synonyms: | CPI 203,CPI203 |
| 分子量: | 399.90 |
| 分子式: | C₁₉H₁₈ClN₅OS |
| SMILES: | ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@H]4CC(N)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPI-203 是一种有效的，选择性的，细胞通透的BET bromodomain抑制剂，抑制BRD4，IC50值约为 37 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Filippakopoulos, P., Qi, J., Picaud, S., et al.Selective inhibition of BET bromodomainsNature468(7327),1067-1073(2010)
King, B., Trimarchi, T., Reavie, L., et al.The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityCell153(7),1552-1566(2013)
Devaiah, B.N., Leiw, B.A., Cherman, N., et al.BRD4 is an atypical kinase that phosphorylates serine 2 of the RNA polymerase II carboxy-terminal domainProc. Natl. Acad. Sci. USA109(18),6927-6932(2012)
