Mdivi-1
Cat. No.：YN270326
CAS No. ：338967-87-6
| 产品名称: | Mdivi-1 |
| CAS No.: | 338967-87-6 |
| Chemical Name: | 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone |
| Synonyms: | Mitochondrial division inhibitor 1 |
| 分子量: | 353.22 |
| 分子式: | C₁₅H₁₀Cl₂N₂O₂S |
| SMILES: | O=C1N(C2=C(Cl)C=C(Cl)C(OC)=C2)C(S)=NC3=C1C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mdivi-1 是选择性的发动蛋白相关蛋白 1 (Drp1) 抑制剂。Mdivi-1 是一种有效的线粒体分裂/线粒体自噬 (mitophagy) 抑制剂。 |
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Cassidy-Stone, A., Chipuk, J.E., Ingerman, E., et al.Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationDev. Cell14(2),193-204(2008)
Wu, D., Dasgupta, A., Chen, K.-H., et al.Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injuryFASEB J.34(1),1447-1464(2020)
Gharanei, M., Hussain, A., Janneh, O., et al.Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: A mitochondrial division/mitophagy inhibitorPLoS One8(10),e77713(2013)
Deng, S., Zhang, L., Mo, Y., et al.Mdivi-1 attenuates lipopolysaccharide-induced acute lung injury by inhibiting MAPKs, oxidative stress and apoptosisPulm. Pharmacol. Ther.62,101918(2020)
