MG 149
Cat. No.：YN270327
CAS No. ：1243583-85-8
| 产品名称: | MG 149 |
| CAS No.: | 1243583-85-8 |
| Chemical Name: | 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid |
| Synonyms: | Tip60 HAT inhibitor |
| 分子量: | 340.46 |
| 分子式: | C₂₂H₂₈O₃ |
| SMILES: | O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MG149 (Tip60 HAT inhibitor) 是Tip60抑制剂，IC50为 74 μM，对 MOF 的抑制性较相似，IC50为 47 μM，而对 PCAF 和 p300 则几乎无活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Legartová, S., Stixová, L., Strnad, H., et al.Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitorsEpigenomics5(4),379-396(2013)
Su, J., Wang, F., Cai, Y., et al.The functional analysis of histone acetyltransferase MOF in tumorigenesisInt. J. Mol. Sci.17(1),(2016)
Ghizzoni, M., Wu, J., Gao, T., et al.6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding siteEur. J. Med. Chem.47(1),337-344(2012)
