DBeQ
Cat. No.：YN270328
| 产品名称: | DBeQ |
| CAS No.: | 177355-84-9 |
| Chemical Name: | N2,N4-bis(phenylmethyl)-2,4-quinazolinediamine |
| Synonyms: | JRF 12 |
| 分子量: | 340.42 |
| 分子式: | C₂₂H₂₀N₄ |
| SMILES: | C1(NCC2=CC=CC=C2)=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DBeQ 是一种有效的，选择性的，ATP 竞争性的p97抑制剂，对 p97(wt) 和 p97(C522A) 的IC50值分别为 1.5 μM 和 1.6 μM，同时可抑制Vps4，IC50值为 11.5 μM。 |
| IC50和靶点: | |
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Chou, T.F., and Deshaies, R.J.Development of p97 AAA ATPase inhibitorsAutophagy7(9),1091-1092(2011)
Chou, T.F., Brown, S.J., Minond, D., et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathwaysProc. Natl. Acad. Sci. USA108(12),4834-4839(2011)
