ELR510444
Cat. No.：YN270335
CAS No. ：1233948-35-0
| 产品名称: | ELR510444 |
| CAS No.: | 1233948-35-0 |
| Chemical Name: | N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-benzenesulfonamide |
| Synonyms: | LR 510444,LR510444,LR-510444 |
| 分子量: | 368.47 |
| 分子式: | C₁₉H₁₆N₂O₂S₂ |
| SMILES: | O=S(C1=CC=C(C)C=C1)(NC2=CC(C3=CC=C(C#N)S3)=CC=C2C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ELR510444是新型微管阻断剂，抑制MDA-MB-231细胞增殖的IC50值为30.9nM，非P-gp底物分子。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Risinger, A.L., Westbrook, C.D., Encinas, A., et al.ELR510444, a novel microtubule disruptor with multiple mechanisms of actionJ. Pharmacol. Exp. Ther.336(3),652-660(2011)
Carew, J.S., Esquivel, J.A., II, Espitia, C.M., et al.ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinomaPLoS One7(1),e31120(2012)
