Forodesine hydrochloride
Cat. No.：YN270336
CAS No. ：284490-13-7
| 产品名称: | Forodesine hydrochloride |
| CAS No.: | 284490-13-7 |
| Chemical Name: | (9CI)-7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-, monohydrochloride 4H-pyrrolo[3,2-d]pyrimidin-4-one; BCX 1770; BCX 1777 |
| Synonyms: | BCX-1777 hydrochloride; Immucillin-H hydrochloride |
| 分子量: | 302.71 |
| 分子式: | C₁₁H₁₅ClN₄O₄ |
| SMILES: | O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Forodesine hydrochloride (BCX-1777 hydrochloride) 是一种高效的口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂，对人，小鼠，大鼠，猴和狗PNP的IC50值在 0.48 至 1.57 nM 之间。Forodesine hydrochloride 是有效的人类淋巴细胞增殖抑制剂，可通过增加 dGTP 水平而诱导白血病细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Fedorov, A., et al.: Biochem., 40, 853 (2001)
