NKP-1339
Cat. No.：YN270339
CAS No. ：197723-00-5
| 产品名称: | NKP-1339 |
| CAS No.: | 197723-00-5 |
| Chemical Name: | (OC-6-11)-tetrachlorobis(1H-indazole-κN2)-ruthenate(1-), monosodium salt |
| Synonyms: | IT-139; KP-1339 |
| 分子量: | 502.14 |
| 分子式: | C₁₄H₁₂Cl₄N₄NaRu |
| SMILES: | [Cl-][Ru+3]([N]1=CC2=CC=CC=C2N1)([Cl-])([Cl-])([N]3=CC4=CC=CC=C4N3)[Cl-].[Na+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NKP-1339 (IT-139; KP-1339) 是针对实体癌开发的一流钌抗癌试剂，副作用小。NKP-1339 通过线粒体途径诱导 G2/M 细胞周期停滞，DNA 合成阻断 (DNA synthesis) 和诱导细胞凋亡 (apoptosis)。NKP-1339 具有很高的肿瘤靶向潜力，与血清蛋白 (serum proteins) 如白蛋白和转铁蛋白强烈结合，并在还原性肿瘤环境中激活。 |
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Kapitza, S., Pongratz, M., Jakupec, M.A., et al.Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cellsJ. Cancer Res. Clin. Oncol.131(2),101-110(2005)
Hudej, R., Turel, I., Kanduser, M., et al.The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivoAnticancer Res.30(6),2055-2063(2010)
