PFI-1
Cat. No.：YN270344
CAS No. ：1403764-72-6
| 产品名称: | PFI-1 |
| CAS No.: | 1403764-72-6 |
| Chemical Name: | 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
| Synonyms: | PFI1,PFI 1,PF-6405761 |
| 分子量: | 347.39 |
| 分子式: | C₁₆H₁₇N₃O₄S |
| SMILES: | O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(N(C)C3)=O)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PFI-1 是一种有效的BET抑制剂，能够有效抑制 BRD4，IC50值为 0.22 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Filippakopoulos, P., Qi, J., Picaud, S., et al.Selective inhibition of BET bromodomainsNature468(7327),1067-1073(2010)
Hewings, D.S., Wang, M., Philpott, M., et al.3,5-Dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligandsJ. Med. Chem.54(19),6761-6770(2011)
Chung, C.W., Coste, H., White, J.H., et al.Discovery and characterization of small molecule inhibitors of the BET family bromodomainsJ. Med. Chem.54(11),3827-3838(2011)
