BIBR 1532
Cat. No.：YN270355
CAS No. ：321674-73-1
| 产品名称: | BIBR 1532 |
| CAS No.: | 321674-73-1 |
| Chemical Name: | 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-benzoic acid |
| Synonyms: | BIBR1532; BIBR-1532 |
| 分子量: | 331.36 |
| 分子式: | C₂₁H₁₇NO₃ |
| SMILES: | O=C(O)C1=CC=CC=C1NC(/C=C(C2=CC=C3C=CC=CC3=C2)\C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIBR 1532 是一种有效的，选择性的telomerase非竞争性抑制剂，IC50值为 100 nM。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Damm, K., Hemmann, U., Garin-Chesa, P., et al.A highly selective telomerase inhibitor limiting human cancer cell proliferationEMBO J.20(24),6958-6968(2014)
Pascolo, E., Wenz, C., Lingner, J., et al.Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidateJ. Biol. Chem.277(18),15566-15572(2002)
Piotrowska, K., Kleideiter, E., Mürdter, T.E., et al.Optimization of the TRAP assay to evaluate specificity of telomerase inhibitorsLab. Invest.85(12),1565-1569(2005)
Phatak, P., and Burger, A.M.Telomerase and its potential for therapeutic interventionBr. J. Pharmacol.152(7),1003-1011(2007)
Wardi, L., Alaaeddine, N., Raad, I., et al.Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: Possible extra-telomerase role of BIBR 1532Cancer Cell Int.14,60(2014)
