Fosbretabulin disodium
Cat. No.：YN270358
CAS No. ：168555-66-6
| 产品名称: | Fosbretabulin disodium |
| CAS No.: | 168555-66-6 |
| Chemical Name: | 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol, dihydrogen phosphate, disodium salt |
| Synonyms: | CA 4DP; CA 4P; Combretastatin A4 disodium phosphate |
| 分子量: | 440.29 |
| 分子式: | C₁₈H₁₉Na₂O₈P |
| SMILES: | COC1=C(OC)C(OC)=CC(/C=C\C2=CC=C(OC)C(OP(O[Na])(O[Na])=O)=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fosbretabulin disodium (CA 4DP) 是微管蛋白去稳定剂。Fosbretabulin disodium 是 Combretastatin A4 前药，可选择性靶向内皮细胞，诱导新生肿瘤新血管消退，减少肿瘤血流量并引起中央肿瘤坏死。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Pettie, G.R., Rhodes, M.R., Herald, D.L., et al.Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-4J. Med. Chem.48(12),4087-4099(2005)
Tozer, G.M., Prise, V.E., Wilson, J., et al.Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissuesCancer Res.59,1626-1634(1999)
