GSK2606414
Cat. No.：YN270359
CAS No. ：1337531-36-8
| 产品名称: | GSK2606414 |
| CAS No.: | 1337531-36-8 |
| Chemical Name: | 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]-ethanone |
| Synonyms: | GSK2606414,GSK-2606414,GSK 2606414 |
| 分子量: | 451.44 |
| 分子式: | C₂₄H₂₀F₃N₅O |
| SMILES: | NC1=C2C(N(C)C=C2C3=CC4=C(N(C(CC5=CC=CC(C(F)(F)F)=C5)=O)CC4)C=C3)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2606414 是可渗透细胞且有口服活性的蛋白激酶 R 样内质网 (ER) 激酶(PERK)抑制剂，IC50值为 0.4 nM。 |
| IC50和靶点: | [{name:"EIF2AK3 (PERK):0.4 nM (IC50)"},{name: "EIF2AK1 (HRI):420 nM (IC50)"},{name: "EIF2AK2 (PKR):696 nM (IC50)"}] |
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| Solvent & Solubility: |
Hetz, C., Chevet, E., and Harding, H.P.Targeting the unfolded protein response in diseaseNat. Rev. Drug Discov.12(9),703-719(2013)
