Prexasertib dihydrochloride
Cat. No.：YN270361
CAS No. ：1234015-54-3
| 产品名称: | Prexasertib dihydrochloride |
| CAS No.: | 1234015-54-3 |
| Chemical Name: | |
| Synonyms: | LY2606368 dihydrochloride |
| 分子量: | 438.31 |
| 分子式: | C₁₈H₂₁Cl₂N₇O₂ |
| SMILES: | NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prexasertib dihydrochloride (LY2606368 dihydrochloride) 是一种选择性的，ATP 竞争性的第二代细胞周期检测点激酶 1 (CHK1) 抑制剂，Ki为 0.9 nM，IC50为 <1 nM。Prexasertib dihydrochloride 抑制 CHK2 (IC50=8 nM) 和 RSK1 (IC50=9 nM)。Prexasertib dihydrochloride 引起双链 DNA 断裂和复制突变，导致细胞凋亡 (apoptosis)。Pre |
| IC50和靶点: | [{name:"Chk1:0.9 nM (Ki)"},{name: "Chk1:<1 nM (IC50)"},{name: "Chk2:8 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
