Prexasertib dimesylate
Cat. No.：YN270363
CAS No. ：1234015-58-7
| 产品名称: | Prexasertib dimesylate |
| CAS No.: | 1234015-58-7 |
| Chemical Name: | |
| Synonyms: | LY2606368 dimesylate |
| 分子量: | 557.60 |
| 分子式: | C₂₀H₂₇N₇O₈S₂ |
| SMILES: | N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prexasertib dimesylate (LY2606368 dimesylate) 是一种选择性的，ATP 竞争性的第二代细胞周期检测点激酶 1 (CHK1) 抑制剂，Ki为 0.9 nM，IC50为 <1 nM。Prexasertib dimesylate 抑制 CHK2 (IC50=8 nM) 和 RSK1 (IC50=9 nM)。Prexasertib dimesylate 引起双链 DNA 断裂和复制突变，导致细胞凋亡 (apoptosis)。Prexasertib dimesylate |
| IC50和靶点: | [{name:"Chk1:0.9 nM (Ki)"},{name: "Chk1:<1 nM (IC50)"},{name: "Chk2:8 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
