Purvalanol A
Cat. No.：YN270364
CAS No. ：212844-53-6
| 产品名称: | Purvalanol A |
| CAS No.: | 212844-53-6 |
| Chemical Name: | (2R)-2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Synonyms: | NG-60 |
| 分子量: | 388.89 |
| 分子式: | C₁₉H₂₅ClN₆O |
| SMILES: | CC([C@@H](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Purvalanol A 是一种有效的CDK抑制剂，对 cdc2-cyclin B，cdc2-cyclin B，cdk2-cyclin E，cdk4-cyclin D1 和 cdk5-p35 的IC50值分别为 4，70，35，850 和 75 nM。 |
| IC50和靶点: | [{name:"cdc2-cyclin B:4 nM (IC50)"},{name: "cdk2-cyclin E:35 nM (IC50)"},{name: "cdk2-cyclin A:70 nM (IC50)"},{name: "cdk4-cyclin D1:850 nM (IC50)"},{name: "cdk5-p35:75 nM (IC50)"},{name: "erk1:9000 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., et al.Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitorsScience281(5376),533-538(1998)
Bain, J., McLauchlan, H., Elliot, M., et al.The specificities of protein kinase inhibitors: An updateBiochem. J.371(Pt. 1),199-204(2003)
Villerbu, N., Gaben, A.M., Redeuilh, G., et al.Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activitiesInt. J. Cancer97,761-769(2002)
Hikita, T., Oneyama, C., and Okada, M.Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-SrcGenes Cells15,1051-1062(2010)
