OTS514
Cat. No.：YN270368
CAS No. ：1338540-63-8
| 产品名称: | OTS514 |
| CAS No.: | 1338540-63-8 |
| Chemical Name: | 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one |
| Synonyms: | OTS514 Hydrochloride,OTS-514,OTS 514,OTS514 HCl |
| 分子量: | 364.46 |
| 分子式: | C₂₁H₂₀N₂O₂S |
| SMILES: | O=C1NC2=C(C(C3=CC=C([C@@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OTS5144 是一种高效的TOPK抑制剂，IC50为 2.6 nM。OTS514 强效抑制 TOPK 阳性的肿瘤细胞生长。OTS514 诱导细胞周期停滞和凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Matsuo, Y., Park, J.H., Miyamoto, T., et al.TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesisSci. Transl. Med.6(259),259ra145(2014)
Alachkar, H., Mutonga, M., Malnassy, G., et al.T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemiaOncotarget6(32),33410-33425(2015)
Kato, T., Inoue, H., Imoto, S., et al.Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cellsOncotarget7(14),17652-17664(2016)
Park, J.-H., Inoue, H., Kato, T., et al.TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancerCancer Sci.108(3),488-496(2017)
Ikeda, Y., Park, J.H., Miyamoto, T., et al.T-LAK cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in ovarian cancerClin. Cancer. Res22(24),6110-6117(2016)
