LDN-57444
Cat. No.：YN270373
CAS No. ：668467-91-2
| 产品名称: | LDN-57444 |
| CAS No.: | 668467-91-2 |
| Chemical Name: | 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) |
| Synonyms: | LDN57444 |
| 分子量: | 397.64 |
| 分子式: | C₁₇H₁₁Cl₃N₂O₃ |
| SMILES: | O=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LDN-57444 是一种可逆的，竞争性的，定向位点的泛素 C 末端水解酶 L1 (UCH-L1) 抑制剂，IC50和Ki值分别为 0.88 μM 和 0.40 μM；LDN-57444 同时可抑制 UCH-L3 的活性，IC50值为 25 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cartier, A.E., Djakovic, S.N., Salehi, A., et al.Regulation of synaptic structure by the ubiquitin C-terminal hydrolase UCH-L1J. Neurosci.29(24),7857-7868(2009)
Liu, Y., Lashuel, H.A., Choi, S., et al.Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell lineChem. Biol.10(9),837-846(2003)
