Dp44mT
Cat. No.：YN270379
CAS No. ：152095-12-0
| 产品名称: | Dp44mT |
| CAS No.: | 152095-12-0 |
| Chemical Name: | 2-(di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide |
| Synonyms: | 2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺 |
| 分子量: | 285.37 |
| 分子式: | C₁₄H₁₅N₅S |
| SMILES: | S=C(N/N=C(C1=NC=CC=C1)\C2=NC=CC=C2)N(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dp44mT是具有选择性抗癌活性的铁螯合剂 (iron chelator)。 |
| IC50和靶点: | |
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Yuan, J., Lovejoy, D.B., and Richardson, D.R.Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessmentBlood104(5),1450-1458(2004)
Dixon, K.M., Lui, G.Y., Kovacevic, Z., et al.Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cellsBr. J. Cancer108(2),409-419(2013)
Jansson, P.J., Yamagishi, T., Arvind, A., et al.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp)J. Biol. Chem.290(15),9588-9603(2015)
Lee, J.-C., Chiang, K.-C., Feng, T.-H., et al.The iron chelator, Dp44mT, effectively inhibits human oral squamous cell carcinoma cell growth in vitro and in vivoInt. J. Mol. Sci.17(9),pii: E1435(2016)
