C-DIM12
Cat. No.：YN270394
CAS No. ：178946-89-9
| 产品名称: | C-DIM12 |
| CAS No.: | 178946-89-9 |
| Chemical Name: | 3,3'-[(4-chlorophenyl)methylene]bis-1H-indole |
| Synonyms: | 3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole;C-DIM12;C-DIM-12;3,3′-[(4-Chlorophenyl)methylene]bis-1H-indole;4-Chlorophenyldi-3-indolylmethane;4-Chlorophenyl-3,3′-diindolylmethane;C-DIMI2;C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane);CDIM12;3,3 |
| 分子量: | 356.85 |
| 分子式: | C₂₃H₁₇ClN₂ |
| SMILES: | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | C-DIM12是一种人工合成的Nurr1激活剂, 诱导Nurr1和DA基因表达。 |
| IC50和靶点: | |
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Inamoto, T., Papineni, S., Chintharlapalli, S., et al.1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growthMol. Cancer Ther.7(12),3825-3833(2008)
De Miranda, B.R., Popichak, K.A., Hammond, S.L., et al.Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's diseaseToxicol. Sci.143(2),360-373(2015)
Sujatha, K., Perumal, P.T., Muralidharan, D., et al.Synthesis, analgesic and anti-inflammatory activities of bis(indolyl)methanesIndian J. Chem.48B(02),267-272(2009)
