4EGI-1
Cat. No.：YN270395
CAS No. ：315706-13-9
| 产品名称: | 4EGI-1 |
| CAS No.: | 315706-13-9 |
| Chemical Name: | α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid |
| Synonyms: | 4EGI 1 |
| 分子量: | 451.28 |
| 分子式: | C₁₈H₁₂Cl₂N₄O₄S |
| SMILES: | O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4EGI-1 是一种eIF4E/eIF4G相互作用抑制剂，抑制 eIF4E 结合，Kd值为 25 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Dever, T.E.Gene-specific regulation by general translation factorsCell108(4),545-556(2002)
Moerke, N.J., Aktas, H., Chen, H., et al.Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4GCell128(2),257-267(2007)
Tamburini, J., Green, A.S., Bardet, V., et al.Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemiaBlood114(8),1618-1627(2009)
Chen, L., Aktas, B.H., Wang, Y., et al.Tumor suppression by small molecule inhibitors of translation initiationOncotarget3(8),869-881(2012)
Hoeffer, C.A., Cowansage, K.K., Arnold, E.C., et al.Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidationProc. Natl. Acad. Sci. USA108(8),3383-3388(2011)
Gkogkas, C.G., Khoutorsky, A., Ran, I., et al.Autism-related deficits via dysregulated eIF4E-dependent translational controlNature493(7432),371-377(2013)
Santini, E., Huynh, T.N., MacAskill, A.F., et al.Exaggerated translation causes synaptic and behavioural aberrations associated with autismNature493(7432),411-415(2013)
Redondo, N., García-Moreno, M., Sanz, M.A., et al.Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1Virology444(1-2),171-180(2013)
