COTI-2
Cat. No.：YN270396
CAS No. ：1039455-84-9
| 产品名称: | COTI-2 |
| CAS No.: | 1039455-84-9 |
| Chemical Name: | 4-(2-pyridinyl)-2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide-1-piperazinecarbothioic acid |
| Synonyms: | COTI 2,COTI2 |
| 分子量: | 366.48 |
| 分子式: | C₁₉H₂₂N₆S |
| SMILES: | S=C(N1CCN(C2=NC=CC=C2)CC1)N/N=C3CCCC4=C\3N=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | COTI-2，一种具有口服活性的，低毒的抗癌药物，是一种第三代 p53 突变体 (p53 mutant) 的激活剂。COTI-2 通过激活突变型 p53 和抑制PI3K/AKT/mTOR途径发挥作用。COTI-2 诱导多种人肿瘤细胞凋亡 (apoptosis)。COTI-2 通过 p53 依赖和非依赖机制在 HNSCC 中具有抗肿瘤活性。COTI-2 将突变型 p53 转化为野生型构象。 |
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Salim, K.Y., Vareki, S.M., Danter, W.R., et al.COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivoOncotarget7(27),(2016)
