PRIMA-1Met
Cat. No.：YN270398
CAS No. ：5291-32-7
| 产品名称: | PRIMA-1Met |
| CAS No.: | 5291-32-7 |
| Chemical Name: | 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
| Synonyms: | APR-246 |
| 分子量: | 199.25 |
| 分子式: | C₁₀H₁₇NO₃ |
| SMILES: | O=C1C(COC)(CO)N2CCC1CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PRIMA-1Met 是一种突变型p53复活剂，可恢复突变型p53的野生型构象和功能，并引发肿瘤细胞凋亡。PRIMA-1Met 还抑制硒蛋白硫氧还蛋白还原酶 1 (TrxR1)。 |
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Bykov, V.J.N., Issaeva, N., Shilov, A., et al.Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compoundNat. Med.8(3),282-288(2002)
Lane, D.P., and Hupp, T.R.Drug discovery and p53Drug Discov. Today8(8),347-355(2003)
Aryee, D.N., Niedan, S., Ban, J., et al.Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcomaBr. J. Cancer109(10),2696-2704(2013)
Bykov, V.J., Zache, N., Stridh, H., et al.PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosisOncogene24(21),3484-3491(2005)
Peng, X., Zhang, M.Q., Conserva, F., et al.APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidaseCell Death Dis.4(10),e881(2013)
