Etomoxir sodium salt
Cat. No.：YN270401
CAS No. ：828934-41-4
| 产品名称: | Etomoxir sodium salt |
| CAS No.: | 828934-41-4 |
| Chemical Name: | (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid monosodium salt |
| Synonyms: | (R)-(+)-Etomoxir sodium salt |
| 分子量: | 320.74 |
| 分子式: | C₁₅H₁₈ClNaO₄ |
| SMILES: | ClC1=CC=C(OCCCCCC[C@@]2(CO2)C(O[Na])=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) 是肉碱棕榈酰转移酶 1a (CPT-1a) 抑制剂，通过抑制 CPT-1a 可抑制脂肪酸氧化，并抑制人、大鼠和豚鼠中棕榈酸酯的氧化。 |
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Portilla, D., Dai, G., Peters, J.M., et al.Etomoxir-induced PPARα-modulated enzymes protect during acute renal failureAm. J. Physiol. Renal. Physiol.278(4),F667-F675(2000)
Lopaschuk, G.D., Wall, S.R., Olley, P.M., et al.Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitineCirc. Res.63(6),1036-1043(1988)
Agius, L., Peak, M., and Sherratt, H.S.A.Differences between human, rat and guinea pig hepatocyte cultures. A comparative study of their rates of β-oxidation and esterification of palmitate and their sensitivity to R-etomoxirBiochem. Pharmacol.42(9),1711-1715(1991)
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Agius, L., Meredith, E.J., and Sherratt, H.S.A.Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytesBiochem. Pharmacol.42(9),1717-1720(1991)
Vacanti, N.M., Divakaruni, A.S., Green, C.R., et al.Regulation of substrate utilization by the mitochondrial pyruvate carrierMol. Cell56(3),425-435(2014)
