Ispinesib
Cat. No.：YN270403
CAS No. ：336113-53-2
| 产品名称: | Ispinesib |
| CAS No.: | 336113-53-2 |
| Chemical Name: | N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methyl-benzamide |
| Synonyms: | 伊斯平斯; SB-715992 |
| 分子量: | 517.06 |
| 分子式: | C₃₀H₃₃ClN₄O₂ |
| SMILES: | O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ispinesib 是一种特异性的纺锤体驱动蛋白KSP抑制剂，Ki app值为 1.7 nM。 |
| IC50和靶点: | [{name:"KSP:1.7 nM (Ki app)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Good, J.A.D., Skoufias, D.A., and Kozielski, F.Elucidating the functionality of kinesins: An overview of small molecule inhibitorsSemin. Cell Dev. Biol.22(9),935-945(2011)
Good, J.A.D., Wang, F., Rath, O., et al.Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft modelsJ. Med. Chem.56(5),1878-1893(2015)
Wang, F., Good, J.A.D., Rath, O., et al.Triphenylbutanamines: Kinesin spindle protein inhibitors with in vivo antitumor activityJ. Med. Chem.55,1511-1525(2012)
Purcell, J.W., Davis, J., Reddy, M., et al.Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancerClin. Cancer Res.16(2),566-576(2010)
Venere, M., Horbinski, C., Crish, J.F., et al.The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastomaSci. Transl. Med.7(304),1-12(2015)
