Tacedinaline
Cat. No.：YN270405
CAS No. ：112522-64-2
| 产品名称: | Tacedinaline |
| CAS No.: | 112522-64-2 |
| Chemical Name: | 4-(acetylamino)-N-(2-aminophenyl)-benzamide |
| Synonyms: | N-acetyldinaline; CI-994; Goe-5549 |
| 分子量: | 269.30 |
| 分子式: | C₁₅H₁₅N₃O₂ |
| SMILES: | O=C(NC1=C(N)C=CC=C1)C2=CC=C(NC(C)=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tacedinaline (N-acetyldinaline) 是组蛋白脱乙酰酶(HDAC)的抑制剂，抑制重组 HDAC 1, 2 和 3 的IC50值分别为 0.9，0.9，1.2 μM。 |
| IC50和靶点: | [{name:"HD1:0.9 μM (IC50)"},{name: "HD2:0.9 μM (IC50)"},{name: "HD3:1.2 μM (IC50)"}] |
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Moradei, O.M., Mallais, T.C., Frechette, S., et al.Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivityJ. Med. Chem.50(23),5543-5546(2007)
El-Beltagi, H.M., Martens, A.C.M., Lelieveld, P., et al.Acetyldinaline: A new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells—preclinical studies in a relevant rat model for human acute myelocytic leukemiaCancer Res.53(13),3008-3014(1993)
LoRusso, P.M., Demchik, L., Foster, B., et al.Preclinical antitumor activity of CI-994Invest. New Drugs14(4),349-356(1996)
Zhang, S., Fujita, Y., Matsuzaki, R., et al.Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injuryCell Death Dis.9(5),460(2018)
