Troglitazone
Cat. No.：YN270406
CAS No. ：97322-87-7
| 产品名称: | Troglitazone |
| CAS No.: | 97322-87-7 |
| Chemical Name: | 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | 曲格列酮; CS-045 |
| 分子量: | 441.54 |
| 分子式: | C₂₄H₂₇NO₅S |
| SMILES: | O=C(SC1CC(C=C2)=CC=C2OCC3(C)OC(C(CC3)=C4C)=C(C)C(C)=C4O)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Troglitazone 是PPARγ的激动剂，对人和鼠 PPARγ的EC50值分别为 550 nM 和 780 nM。 |
| IC50和靶点: | [{name:"PPARγ:550 nM (EC50, Human PPARγ)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Willson, T.M., Brown, P.J., Sternbach, D.D., et al.The PPARs: From orphan receptors to drug discoveryJ. Med. Chem.43(4),527-550(2000)
Henke, B.R., Blanchard, S.G., Brackeen, M.F., et al.N-(2-Benzoylphenyl)-L-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agentsJ. Med. Chem.41(25),5020-5036(1998)
Yoshizawa, K., Cioca, D.P., Kawa, S., et al.Peroxisome proliferator-activated receptor γ ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell linesCancer95(10),2243-2251(2002)
