GSK-1070916
Cat. No.：YN270409
CAS No. ：942918-07-2
| 产品名称: | GSK-1070916 |
| CAS No.: | 942918-07-2 |
| Chemical Name: | N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-urea |
| Synonyms: | GSK1070916,GSK-1070916A |
| 分子量: | 507.63 |
| 分子式: | C₃₀H₃₃N₇O |
| SMILES: | O=C(NC1=CC=C(C2=NN(C=C2C3=C4C(NC(C5=CC=CC(CN(C)C)=C5)=C4)=NC=C3)CC)C=C1)N(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK-1070916是有效，选择性，ATP竞争型的极光激酶B/C (aurora B/C) 抑制剂，Ki值分别为0.38和1.5 nM。 |
| IC50和靶点: | [{name:"Aurora B:0.38 nM (Ki)"},{name: "Aurora C:1.5 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Adams, N.D., Adams, J.L., Burgess, J.L., et al.Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinaseJ. Med. Chem.53(10),3973-4001(2010)
Hardwicke, M.A., Oleykowski, C.A., Plant, R.N., et al.GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft modelsMol. Cancer. Ther.8(7),1808-1817(2009)
