Clofarabine
Cat. No.：YN270412
| 产品名称: | Clofarabine |
| CAS No.: | 123318-82-1 |
| Chemical Name: | 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
| Synonyms: | 氯法拉滨 |
| 分子量: | 303.68 |
| 分子式: | C₁₀H₁₁ClFN₅O₃ |
| SMILES: | F[C@H]([C@H](N1C2=C(C(N)=NC(Cl)=N2)N=C1)O[C@@H]3CO)[C@@H]3O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clofarabine(Clolar; Clofarex)能抑制核苷酸还原酶，IC50为65 nM，还能抑制DNA聚合酶活性。 |
| IC50和靶点: | |
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Parker, W.B., Shaddix, S.C., Chang, C.H., et al.Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphateCancer Res.51,2386-2394(1991)
Genini, D., Adachi, S., Chao, Q., et al.Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondriaBlood96(10),3537-3543(2000)
Yamauchi, T., Nowak, B.J., Keating, M.J., et al.DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabineClin. Cancer Res.7,3580-3589(2001)
Chiarini, F., Lonetti, A., Teti, G., et al.A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemiaOncotarget3(12),1615-1628(2012)
Lee, Y.J., Im, J.H., Lee, D.M., et al.Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulationBMB Rep.45(11),647-652(2012)
