Fludarabine phosphate
Cat. No.：YN270416
CAS No. ：75607-67-9
| 产品名称: | Fludarabine phosphate |
| CAS No.: | 75607-67-9 |
| Chemical Name: | 2-fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine |
| Synonyms: | 磷酸氟达拉滨; NSC 118218 phosphate |
| 分子量: | 365.21 |
| 分子式: | C₁₀H₁₃FN₅O₇P |
| SMILES: | NC1=C2C(N([C@H]3[C@@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)C=N2)=NC(F)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fludarabine phosphate (NSC 118218 phosphate) 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，导致 DNA 合成受阻。 |
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Elhasasna, H., Khan, R., Bhanumathy, K.K., et al.A drug repurposing screen identifies fludarabine phosphate as a potential therapeutic agent for N-MYC overexpressing neuroendocrine prostate cancersCells11(14),2246(2022)
Mittelman, A., Savona, S., Puccio, C., et al.Phase II trial of fludarabine phosphate (F-Ara-AMP) in patients with advanced head and neck cancerInvest. New Drugs8,S65-S67(1990)
Plunkett, W., Chubb, S., Alexander, L., et al.Comparison of the toxicity and metabolism of 9-β-D-arabinofuranosyl-2-fluoroadenine and 9-β-D-arabinofuranosyladenine in human lymphoblastoid cellsCancer Res.40(7),2349-2355(1980)
Zhao, J., Liu, Q., Yi, D., et al.5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesisAntiviral Res.198,105254(2022)
