Dacarbazine
Cat. No.：YN270418
CAS No. ：4342-03-4
| 产品名称: | Dacarbazine |
| CAS No.: | 4342-03-4 |
| Chemical Name: | 5-(3,3-dimethyl-1-triazen-1-yl)-1H-imidazole-4-carboxamide |
| Synonyms: | 达卡巴嗪; Imidazole Carboxamide |
| 分子量: | 182.18 |
| 分子式: | C₆H₁₀N₆O |
| SMILES: | O=C(C1=C(/N=N/N(C)C)NC=N1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dacarbazine(DTIC-Dome; DTIC)有抗黑色素瘤活性。 |
| IC50和靶点: | |
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Marchesi, F., Turriziani, M., Tortorelli, G., et al.Triazene compounds: Mechanism of action and related DNA repair systemsPharmacol. Res.56(4),275-287(2007)
Jin, J.-l., Gong, J., Yin, T.-j., et al.PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivoEur. J. Pharmacol.654(1),17-25(2011)
Valiahdi, S.M., Heffeter, P., Jakupec, M.A., et al.The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell linesMelanoma Res.19(5),283-293(2009)
