Tebufenozide
Cat. No.：YN270431
| 产品名称: | Tebufenozide |
| CAS No.: | 112410-23-8 |
| Chemical Name: | 3,5-dimethyl-1-(1,1-dimethylethyl)-2-(4-ethylbenzoyl)hydrazide, benzoic acid |
| Synonyms: | |
| 分子量: | 352.47 |
| 分子式: | C₂₂H₂₈N₂O₂ |
| SMILES: | O=C(N(C(C)(C)C)NC(C1=CC=C(CC)C=C1)=O)C2=CC(C)=CC(C)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tebufenozide 是一种用于防治害虫的非甾体外泌素激动剂。Tebufenozide 具有细胞毒性， 能诱导 HeLa 细胞和 Tn5B1-4 昆虫细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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Yokoi, T., Minami, S., Nakagawa, Y., et al.Structure-activity relationship of imidazothiadiazole analogs for the binding to the ecdysone receptor of insect cellsPestic. Biochem. Physiol.120,40-50(2015)
Miyata, K.-i., Nakagawa, Y., Kimura, Y., et al.Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transportBioorg. Med. Chem.24(14),3184-3191(2016)
Xu, W., Wang, B., Yang, M., et al.Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cellsEnviron. Toxicol. Pharmacol.49,89-96(2017)
Abass, K.M.An investigation into the formation of tebufenozide's toxic aromatic amine metabolites in human in vitro hepatic microsomesPestic. Biochem. Physiol.133,73-78(2016)
