(S)-10-Hydroxycamptothecin
Cat. No.：YN270443
| 产品名称: | (S)-10-Hydroxycamptothecin |
| CAS No.: | 19685-09-7 |
| Chemical Name: | (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Synonyms: | 10-羟基喜树碱; 10-HCPT; 10-Hydroxycamptothecin |
| 分子量: | 364.35 |
| 分子式: | C₂₀H₁₆N₂O₅ |
| SMILES: | O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) 是一种从喜树中分离的 DNA 拓扑异构酶 I (DNA topoisomerase I) 抑制剂。(S)-10-Hydroxycamptothecin 可显着诱导细胞凋亡，并可用于肝癌，胃癌，结肠癌和白血病的研究。 |
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Drwal, M.N., Agama, K., Wakelin, L.P.G., et al.Exploring DNA topoisomerase I ligand space in search of novel anticancer agentsPLoS One6(9),1-12(2011)
Yu, P., Xia, L., Zhao, J., et al.Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogsBiol. Pharm. Bull.35(8),1295-1299(2012)
Zhang, X.W., Jiang, J.F., and Xu, B.Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cellsActa Pharmacol. Sin.21(4),364-368(2000)
