Curcumol
Cat. No.：YN270444
CAS No. ：4871-97-0
| 产品名称: | Curcumol |
| CAS No.: | 4871-97-0 |
| Chemical Name: | (3S,3aS,5S,6R,8aS)-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol |
| Synonyms: | 莪术醇; (-) |
| 分子量: | 236.35 |
| 分子式: | C₁₅H₂₄O₂ |
| SMILES: | O[C@@]1(C2)[C@H](C(C)C)C[C@]3(O1)[C@@H](C)CC[C@@]3([H])C2=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Curcumol ((-)-Curcumol) 是一种具有生物活性的倍半萜，具有许多药理活性，例如抗癌，抗微生物，抗真菌，抗病毒和抗炎。Curcumol 通过靶向关键信号通路 (如 MAPK/ERK，PI3K/Akt 和 NF-κB) 而在许多癌细胞中有效地诱导凋亡 (apoptosis)，这些信号通路在几种癌症中通常被异常调节。 |
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Liu, Y.-M., Fan, H.-R., Ding, J., et al.Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepinesSci. Rep.7:46654,(2017)
Li, N., Liu, T.-H., Yu, J.-Z., et al.Curcumin and curcumol inhibit NF-κB and TGF-β1/Smads signaling pathways in CSE-treated RAW246.7 cellsEvid. Based Complement. Alternat. Med.,3035125(2019)
Wang, J., Huang, F., Bai, Z., et al.Curcumol inhibits growth and induces apoptosis of colorectal cancer LoVo cell line via IGF-1R and p38 MAPK pathwayInt. J. Mol. Sci.16(8),19851-19867(2015)
Zhou, J., Ni, M., Liu, X., et al.Curcumol promotes vascular endothelial growth factor (VEGF)-mediated diabetic wound healing in streptozotocin-induced hyperglycemic ratsMed. Sci. Monit.23,555-562(2017)
