Dioscin
Cat. No.：YN270447
| 产品名称: | Dioscin |
| CAS No.: | 19057-60-4 |
| Chemical Name: | (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside |
| Synonyms: | 薯蓣皂甙; Collettiside III; CCRIS 4123 |
| 分子量: | 869.04 |
| 分子式: | C₄₅H₇₂O₁₆ |
| SMILES: | O[C@@H]1[C@@H](O)[C@H](C)O[C@@]([H])(O[C@H]2[C@H](O)[C@@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@](O[C@@H]4CC5=CC[C@]([C@]([H])(C[C@@]6([H])[C@]7([H])[C@H](C)[C@]8(OC[C@H](C)CC8)O6)[C@]7(C)CC9)([H])[C@@]9([H])[C@@]5(C)CC4)([H])O[C@@H]2CO)[C@@H |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷，针对多种癌细胞有较好的抗癌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Xu, X.-H., Li, T., Fong, C.M., et al.Saponins from Chinese medicines as anticancer agentsMolecules21(10),pii:E1326(2016)
Cai, J., Liu, M., Wang, Z., et al.Apoptosis induced by dioscin in Hela cellsBiol. Pharm. Bull.25(2),193-196(2002)
Lee, K.J., Oh, Y.C., Cho, W.K., et al.Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assayEvid. Based Complement. Alternat. Med.,165457(2015)
Zhou, Q., Song, W., and Xiao, W.Dioscin induces demethylation of DAPK-1 and RASSF-1α genes via the antioxidant capacity, resulting in apoptosis of bladder cancer T24 cellsEXCLI J.16,101-112(2017)
Hsieh, M.-J., Tsai, T.-L., Hsieh, Y.-S., et al.Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell linesArch. Toxicol.87(11),1927-1937(2013)
