Vincristine sulfate
Cat. No.：YN270466
CAS No. ：2068-78-2
| 产品名称: | Vincristine sulfate |
| CAS No.: | 2068-78-2 |
| Chemical Name: | 22-oxo-vincaleukoblastine sulfate |
| Synonyms: | 硫酸长春新碱; Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate |
| 分子量: | 923.04 |
| 分子式: | C₄₆H₅₈N₄O₁₄S |
| SMILES: | CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC([C@](C5=C6C7=CC=CC=C7N5)(C[C@](C[C@](CC)(O)C8)([H])C[N@@]8CC6)C(OC)=O)=C(OC)C=C4N9C=O)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=S(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vincristine sulfate是一种抗肿瘤长春花生物碱，抑制有丝分裂纺锤体中的microtubule形成，导致中期阶段的分裂细胞停滞。 它与microtubule结合的Ki为85 nM。 |
| IC50和靶点: | |
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Jordan, M.A., Himes, R.H., and Wilson, L.Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitroCancer Res.45(6),2741-2747(1985)
Towle, M.J., Salvato, K.A., Wels, B.F., et al.Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditionsCancer Res.71(2),496-505(2011)
van Tellingen, O., Buckle, T., Jonker, J.W., et al.P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivoBr. J. Cancer89(9),1776-1782(2003)
Chan, H.S.L., Haddad, G., Thorner, P.S., et al.P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastomaNew Engl. J. Med.325(23),1608-1614(1991)
