Demethylzeylasteral
Cat. No.：YN270471
CAS No. ：107316-88-1
| 产品名称: | Demethylzeylasteral |
| CAS No.: | 107316-88-1 |
| Chemical Name: | (9β,13α,14β,20α)-2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid |
| Synonyms: | 去甲泽拉木醛 |
| 分子量: | 480.59 |
| 分子式: | C₂₉H₃₆O₆ |
| SMILES: | C[C@](C1=CC2=O)(CC[C@]3(C)[C@@]4([H])C[C@@](C(O)=O)(C)CC3)[C@]4(CC[C@]1(C5=C2C(C=O)=C(O)C(O)=C5)C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Demethylzeylasteral 是从雷公藤中分离出的一种三萜烯化合物，具有抗炎、免疫抑制和抗肿瘤活性。Demethylzeylasteral 能显著减轻动脉粥样硬化 (AS)。Demethylzeylasteral 通过阻断典型和非典型 TGF-β 信号通路，抑制三阴性乳腺癌入侵。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ushiro, S., Ono, M., Nakayama, J., et al.New nortriterpenoid isolated from anti-rheumatoid arthritic plant, Tripterygium wilfordii, modulates tumor growth and neovascularizationInt. J. Cancer72(4),657-663(1997)
Zhao, J.-W., Wang, G.-H., Chen, M., et al.Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7Molecules17(8),9469-9475(2012)
Hu, Q., Yang, C., Wang, Q., et al.Demethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB PathwayPLoS One10(7),e0133724(2015)
Xu, W., Lin, Z., Yang, C., et al.Immunosuppressive effects of demethylzeylasteral in a rat kidney transplantation modelInt. Immunopharmacol.9(7-8),996-1001(2009)
