Flavokawain B
Cat. No.：YN270511
CAS No. ：1775-97-9
| 产品名称: | Flavokawain B |
| CAS No.: | 1775-97-9 |
| Chemical Name: | (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one |
| Synonyms: | Flavokavain B |
| 分子量: | 284.31 |
| 分子式: | C₁₇H₁₆O₄ |
| SMILES: | O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中分离出的查尔酮，是一种抑制各种癌细胞株生长的有效凋亡诱导剂。(Flavokavain B) 具有很强的抗血管生成活性。(Flavokavain B) 以极低的无毒浓度抑制人脑内皮细胞 (HUVEC) 的迁移和血管形成。 |
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Tang, Y., Xuesen, L., Zhongbo, L., et al.Flavokawain B, a kava chalcone, exhibits robust apoptotic mechanisms on androgen receptor-negative, hormone-refractory prostate cancer cell lines and reduces tumor growth in a preclinical modelInt. J. Cancer127(8),1758-1768(2010)
Eskander, R.N., Randall, L.M., Sakai, T., et al.Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell lineJ. Obstet. Gynaecol. Res.38(8),1086-1094(2012)
Zhou, P., Gross, S., Liu, J.H., et al.Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathwaysFASEB J.24(12),4722-4732(2010)
