Hirsutine
Cat. No.：YN270514
| 产品名称: | Hirsutine |
| CAS No.: | 7729-23-9 |
| Chemical Name: | (αE,2S,3R,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester |
| Synonyms: | 毛钩藤碱 |
| 分子量: | 368.47 |
| 分子式: | C₂₂H₂₈N₂O₃ |
| SMILES: | O=C(OC)/C([C@H]([C@H](CN1CC2)CC)C[C@]1([H])C3=C2C(C=CC=C4)=C4N3)=C/OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hirsutine，一种Uncaria rhynchophylla的吲哚生物碱，具有抗癌活性。Hirsutine 诱导细胞凋亡，并且是一种有效的Dengue virus抑制剂，具有低毒性。 |
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Qi, W., Yue, S.-J., Sun, J.-H., et al.Alkaloids from the hook-bearing branch of Uncariarhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell deathJ. Asian Nat. Prod. Res.16(8),876-883(2014)
Zhang, R., Li, G., Zhang, Q., et al.Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cellsCell Death Dis.9(6),598(2018)
Brunhofer, G., Fallarero, A., Karlsson, D., et al.Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrineBioorg. Med. Chem.20(22),6669-6679(2012)
Jiang, W., Zhang, Y., Zhang, W., et al.Hirsutine ameliorates myocardial ischemia-reperfusion injury through improving mitochondrial function via CaMKII pathwayClin. Exp. Hypertens.45(1),2192444(2023)
