Deoxypodophyllotoxin
Cat. No.：YN270528
| 产品名称: | Deoxypodophyllotoxin |
| CAS No.: | 19186-35-7 |
| Chemical Name: | (5R,5aR,8aR)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
| Synonyms: | 脱氧鬼臼毒素 |
| 分子量: | 398.41 |
| 分子式: | C₂₂H₂₂O₇ |
| SMILES: | O=C1[C@]2([H])[C@H](C3=CC(OC)=C(OC)C(OC)=C3)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Deoxypodophyllotoxin (DPT)，鬼臼毒素的衍生物，是一种木酚素，从Sinopodophullumhexandrum(小檗科)的根茎分离，具有强效抗有丝分裂和抗病毒特性。Deoxypodophyllotoxin 作为靶向微管的药物，不仅抗有丝分裂剂而且作为有效的血管生成抑制剂，在肿瘤学中具有重大影响。Deoxypodophyllotoxin 诱导细胞自噬 (autophagy) 和细胞凋亡 (apoptosis)。_x000D_ Deoxypodophyllotoxin 引起 DRG |
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Gamage, C.D.B., Park, S.-Y., Yang, Y., et al.Deoxypodophyllotoxin exerts anti-cancer effects on colorectal cancer cells through induction of apoptosis and suppression of tumorigenesisInt. J. Mol. Sci.20(11),2612(2019)
Lee, S.H., Son, M.J., Ju, H.K., et al.Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cellsBiol. Pharm. Bull.27(6),786-788(2004)
Sudo, K., Konno, K., Shigeta, S., et al.Inhibitory effects of podophyllotoxin derivatives on herpes simplex virus replicationAntivir. Chem. Chemother.9(3),263-267(1998)
Chen, J.-J., Chang, Y.-L., Teng, C.-M., et al.Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifoliaPlanta Med.66(3),251-256(1999)
Gao, R., Gao, C., Tian, X., et al.Insecticidal activity of deoxypodophyllotoxin, isolated from Juniperus sabina L, and related lignans against larvae of Pieris rapae LPest Manag. Sci.60(11),1131-1136(2004)
