Destruxin B
Cat. No.：YN270566
| 产品名称: | Destruxin B |
| CAS No.: | 2503-26-6 |
| Chemical Name: | cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl] |
| Synonyms: | 黑僵菌素 B |
| 分子量: | 621.81 |
| 分子式: | C₃₂H₅₅N₅O₇ |
| SMILES: | O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Destruxin B 是从昆虫病原真菌中分离的绿僵菌 (Metarhizium anisopliae)，是一种具有杀虫和抗癌活性的环肽。 Destruxin B 通过Bcl-2 家族依赖的线粒体途径在人类非小细胞肺癌细胞中诱导细胞凋亡。Destruxin B 显著激活caspase-3，并在体外和体内通过 caspase 介导的细胞凋亡减少肿瘤细胞增殖。 |
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Pedras, M., Zaharia, L.I., and Ward, D.E.The destruxins: Synthesis, biosynthesis, biotransformation, and biological activityPhytochemistry59(6),579-596(2002)
Berthiller, F., Crews, C., Dall'Asta, C., et al.Masked mycotoxins: A reviewMol. Nutr. Food Res.57,165-186(2013)
Pedras, M.S., Zaharia, I.L., Gai, Y., et al.In planta sequential hydroxylation and glycosylation of a fungal phytotoxin: Avoiding cell death and overcoming the fungal invaderProc. Natl. Acad. Sci. USA,(2001)
Wu, C.-C., Chen, T.-H., Liu, B.-L., et al.Destruxin B isolated from entomopathogenic fungus Metarhizium anisopliae induces apoptosis via a Bcl-2 family-dependent mitochondrial pathway in human nonsmall cell lung cancer cellsEvid. Based Complement. Alternat. Med.2013:548929,(2013)
