Chaetoglobosin A
Cat. No.：YN270570
| 产品名称: | Chaetoglobosin A |
| CAS No.: | 50335-03-0 |
| Chemical Name: | (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione |
| Synonyms: | |
| 分子量: | 528.64 |
| 分子式: | C₃₂H₃₆N₂O₅ |
| SMILES: | O=C(/C=C/C1=O)[C@H](O)/C(C)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]31C(N[C@@H](CC4=CNC5=C4C=CC=C5)[C@]3([H])[C@H](C)[C@]6(C)[C@@]2([H])O6)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chaetoglobosin A 是青霉 (Penicillium aquamarinium) 提取物中的活性成分，是细胞松弛素家族 (cytochalasan family) 的成员。 Chaetoglobosin A 优先诱导细胞凋亡 (apoptosis)。Chaetoglobosin A 靶向 CLL 细胞中的丝状肌动蛋白 (filamentous actin)，从而诱导细胞周期停滞并抑制膜皱褶和细胞迁移。 |
| IC50和靶点: | |
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Cui, C.M., Li, X.M., Li, C.S., et al.Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14J. Nat. Prod.73(4),729-733(2010)
Yahara, I., Harada, F., Sekita, S., et al.Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitroJ. Cell Biol.92(1),69-78(1982)
Hu, Y., Zhang, W., Zhang, P., et al.Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognitaJ. Agric. Food Chem.61(1),41-46(2013)
Knudsen, P.B., Hanna, B., Ohl, S., et al.Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeletonLeukemia28(6),1289-1298(2014)
