Chlamydocin
Cat. No.：YN270609
| 产品名称: | Chlamydocin |
| CAS No.: | 53342-16-8 |
| Chemical Name: | cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl] |
| Synonyms: | |
| 分子量: | 526.62 |
| 分子式: | C₂₈H₃₈N₄O₆ |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chlamydocin，一种真菌代谢产物，是一种高效的HDAC抑制剂，IC50为 1.3 nM。Chlamydocin 具有很强的抗增殖和抗癌活性。Chlamydocin 通过激活 caspase-3 诱导细胞凋亡。 |
| IC50和靶点: | [{name:"HDAC:1.3 nM (IC50)"}] |
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| Clinical Trial: | |
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De Schepper, S., Bruwiere, H., Verhulst, T., et al.Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivinJ. Pharmacol. Exp. Ther.304(2),881-888(2003)
Furumai, R., Komatsu, Y., Nishino, N., et al.Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxinProc. Natl. Acad. Sci. USA98(1),87-92(2001)
Stähelin, H., and Trippmacher, A.Cytostatic activity of chlamydocin, a rapidly inactivated cyclic tetrapeptideEur. J. Cancer10(12),801-808(1974)
