Phytosphingosine
Cat. No.：YN270619
CAS No. ：554-62-1
| 产品名称: | Phytosphingosine |
| CAS No.: | 554-62-1 |
| Chemical Name: | 2S-amino-1,3S,4R-octadecanetriol |
| Synonyms: | |
| 分子量: | 317.51 |
| 分子式: | C₁₈H₃₉NO₃ |
| SMILES: | CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phytosphingosine 是一种磷脂，具有抗癌作用。在癌细胞中，Phytosphingosine 通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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Schürer, N.Y., Plewig, G., and Elias, P.M.Stratum corneum lipid functionDermatologica183(2),77-94(1991)
Kondo, N., Ohno, Y., Yamagata, M., et al.Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acidsNat. Commun.5,5338(2014)
Lee, J.S., Min, D.S., Park, C., et al.Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptorFEBS. Lett.499(1-2),82-86(2001)
Hannun, Y.A., Luberto, C., and Argraves, K.M.Enzymes of sphingolipid metabolism: From modular to integrative signalingBiochemistry40(16),4893-4903(2001)
