CPTH2
Cat. No.：YN270623
CAS No. ：357649-93-5
| 产品名称: | CPTH2 |
| CAS No.: | 357649-93-5 |
| Chemical Name: | 2-[4-(4-Chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone; 4-(4-Chlorophenyl)-2(3H)-thiazolone-cyclopentylidenehydrazone; |
| Synonyms: | |
| 分子量: | 291.80 |
| 分子式: | C₁₄H₁₄ClN₃S |
| SMILES: | ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPTH2 是有效的组蛋白乙酰基转移酶 (HAT) 抑制剂。CPTH2 选择性地抑制Gcn5对组蛋白 H3 的乙酰化。CPTH2 通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡 (apoptosis) 并降低透明细胞肾癌 (ccRCC) 细胞系的侵袭性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chimenti, F. et al.: J. Med. Chem., 52, 530 (2009)
Chimenti, F. et al.: Bioorg. Med. Chem., 17, 4635 (2007)
